evaluation of anti-pyretic potential of ichnocarpus frutescens roots

the methanol extract of ichnocarpus frutescens r.br. root (meif) was evaluated for its anti-pyretic potential on normal body temperature and yeast-induced pyrexia in albino rats. yeast suspension (10 ml/kg body wt.) increased rectal temperature 19 h after subcutaneous injection. the meif, at doses of 100, 200, and 300 mg/kg body wt., p.o., produced significant reduction in normal body temperature and yeast-provoked elevated temperature in a dose dependent manner. the effect extended up to 5 h after the drug administration. the anti-pyretic effect of meif was comparable to that of paracetamol (150 mg/kg body wt., p.o.), a standard anti-pyretic agent.